My Score is a customizable scoring system in DISGENET that allows you to prioritize gene–disease or variant–disease associations based on the evidence sources most relevant to your research.

Different research questions require different types of evidence. For example, some workflows rely on expert-curated databases, while others prioritize large-scale population studies, pharmacogenomics datasets, or clinical evidence.

With My Score, you can adjust how these evidence sources contribute to the final ranking of associations.

How My Score works

DISGENET integrates information from multiple data sources to calculate association scores.
With My Score, you can:

• Select the evidence sources most relevant to your analysis (e.g., specialized databases like Orphanet for rare diseases, or data from Biobanks, the GWAS Catalog for complex diseases).

• Assign custom weights to each source according to its importance for your case study.

• Let DISGENET automatically apply My Score to the results of your search.

• Save scoring configurations and reuse them across datasets or analyses.

By adjusting the contribution of each source, My Score helps you highlight the associations that best match your use case objectives.

Assigning weights to evidence sources

Weights determine how much influence each evidence source has on the final score.

• Each source is assigned a numeric weight between 0 and 1.

• The total of all weights must equal 1.

• Higher weights give greater importance to that evidence source.

In this configuration:

• Clinical Trials evidence contributes 50% to the final score

• Literature-derived evidence contributes 30%

• GWAS data contributes 20%

DISGENET combines these weighted contributions to generate the My Score value, which is then used to filter and rank associations in your results.

The My Score feature is available in DISGENET Standard and Advanced plans.